HT4000E SPE-LC Workstation

HT4000E – Automate your Solid Phase Extraction

HT4000E: SPE-LC Sample Prep Workstation

HT4000E is a flexible HPLC autosampler that can automate your Solid Phase Extraction routine. It takes care of sample purification up to the collection of eluted sample in vials (offline mode) or can proceed further up to the direct injection into the HPLC or LC-MS analyzer (online mode).


Does more than any HPLC autosampler

Sample preparation accounts for up to 85% of the time taken for an analytical process. Therefore, it is important to select the correct instrumentation to fully maximize the process to give optimum results: HT4000E combining both SPE automation and HPLC autosampler capability is the prefect instrument to achieve your goals.

Robust Technology

Check the brochure and view the video below to learn more about workstation operations. In a very small bench space, HT4000E is able to provide automation up to 32 samples; for each sample the purification volume can be as large as 50ml. You can customize the sample racks to fit your applications and lab workflow.

Constant Flow Technology

The constant flow technology eliminates the SPE cartridge lot-to-lot reproducibility issue that is typical of systems based on constant pressure technology. Thanks to Constant Flow Technology, washing and elution are performed at a constant flow (no vacuum or gas pressure required), ensuring constant elution times for all the analyzed samples.

Easy SPE method design

HTAPREP software controls HT4000E: it gets users up to speed quickly and allows thm to run samples immediately. Each sample can have a multiple-step methodology providing the flexibility required. The software uses an intuitive powerful drag and drop interface to allow the unit to control every individual aspect of the SPE process. This includes sample loading, washing, drying, flushing, elution, derivatization as well as HPLC/LC-MS injection

Not only SPE: Do more with your HT4000E!

HT4000E support a wide-range of clean-up procedures. Besides most common SPE cartridges (Normal, Reversed and Ion Exchange phases), HT4000E can be used for Affinity and Immunoaffinity cartridges as per Diatomaceous Earth Sorbent SLE cartridges. Furthermore HT4000E can be successfully used to automate sample filtration by the usage of filter cartridges, a substitute of the syringe filters.

HTAPREP: Lab Automation Software

HTAPREP is a brilliant software utility that assist in the management of simple or complex routines for laboratory automation. HTAPREP allows the definition of the methods, execution of sample lists and everything you may need for your lab automation needs.



For HTA instruments and third-party devices

HTAPREP is available in multiple editions that differentiate themselves in relation to the number and to the type of included instrument controls. It has been designed to control several HTA instruments; however, it also supports third-party devices (such as microbalances, barcode readers…) for a richer user experience.

Easy method editing: you do not need to code

In HTAPREP, writing a method from scratch or editing an existing method has never been so easy: drag & drop function addictions and graphical representation of the method ensures a fast development. 
Before validating your method, rapidly spot and solve problems by leveraging HTAPREP parameter validation, error discovery tool and debug-mode run. You will be able to create a robust method in a short time.

Smart processing engine

We offer multiple ways to process your samples: serial (process one sample to the end before moving to the next sample); parallel (perform the same step on all the samples before moving to the following step) or batch (perform the same step on a batch of samples before moving to the next step for the same batch). Therefore, you are able to define the best strategy according to your goals: to optimise productivity, to reduce reagent consumption or to handle time-critical steps.

Stunning user interface

Multiple access level – before being a GLP software requirement – is a software usability need: varied audience means, in fact, different needs and different software usage patterns. User interface has been carefully designed to be clear and effective: the various tools are grouped using the popular ribbon design first introduced by Microsoft Office: contextual elements will only appear when needed, thus greatly simplifying the overall experience.

Powerful tools: Advanced Usage Pattern

HTAPREP comes with many tools and functionalities to help you design the most smart and complete lab automation experience as fast and easily as possible such as: timer events, function iteration, management of unexpected events. Furthermore, for OEM and Value-Added Integrator, we offer application distribution functionalities.